Would it be possible to set the Serial connection to prompt for which COM port to use when you start the session? This function is available in MobaXTerm (see attached screenshots).
Depending on which USB port I use on my laptop or docking station, I get a different Active COM Port number.
IE. When I use the USB port on the right side of my laptop when I am in the field, it is COM2. When I use a USB port on my docking station in the office, it is COM5.
Having this feature makes it a lot easier to connect via Serial in different situations. Instead of having to have either separate sessions saved, or editing the session properties every time.